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ea0037gp.30.07 | Endocrine tumours and neoplasia – General | ECE2015

Steroid metabolome analysis reveals that prostate cancer has potent 5α-reductase, 3α- and 17β-hydroxysteroid dehydrogenase activities, but lacks 17-hydroxylase/17,20-lyase

Hofland Johannes , Taylor Angela E , Turgeman Orli , O'Neil Donna M , Foster Paul A , Arlt Wiebke

Introduction: Prostate cancer (PC) is dependent on androgen receptor (AR) activation by its canonical ligands testosterone and 5α-dihydrotestosterone (DHT). Intratumoural androgens persisting after castration give rise to castration-resistant PC (CRPC). These intraprostatic androgen levels are hypothesized to result from either adrenal androgen conversion or intratumoural de novo DHT synthesis through the classic or alternative pathways. Quantifying the steroid f...

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Endocrine Abstracts

Steroid metabolome analysis reveals that prostate cancer has potent 5α-reductase, 3α- and 17β-hydroxysteroid dehydrogenase activities, but lacks 17-hydroxylase/17,20-lyase

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